Tv Tonight: Golden Globe Awards and Downton Abbey
In the motion picture drama division, nominees include “The Descendants,” “The Help,” “Hugo,” “The Ides of March,” “Moneyball” and “War Horse” for best picture; Glenn Close, Viola Davis, Rooney Mara, Meryl Streep and Tilda Swinton for best actress; and George Clooney, Leonardo DiCaprio, Michael Fassbender, Ryan Gosling and Brad Pitt for best actor.
Sun, 15 Jan 2012 22:38:43 GMT
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New Research Says People with Psoriasis at Great Risk of Heart Disease
NY Dermatologist Joshua Fox, MD offers tips for best treatments for Psoriasis.
(PRWeb January 08, 2012)
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Interferon and Biologic Signatures in Dermatomyositis Skin: Specificity and Heterogeneity across Diseases.
PLoS One. 2012; 7(1): e29161
Wong D, Kea B, Pesich R, Higgs BW, Zhu W, Brown P, Yao Y, Fiorentino D
Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood.We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of interferon (IFN)-inducible genes in DM skin, as well as several other gene modules pertaining to inflammation, complement activation, and epidermal activation and differentiation. The interferon (IFN)-inducible genes within the DM signature were present not only in DM and lupus, but also cutaneous herpes simplex-2 infection and to a lesser degree, psoriasis. This IFN signature was absent or weakly present in atopic dermatitis, allergic contact dermatitis, acne vulgaris, systemic sclerosis, and localized scleroderma/morphea. We observed that the IFN signature in DM skin appears to be more closely related to type I than type II IFN based on in vitro IFN stimulation expression signatures. However, quantitation of IFN mRNAs in DM skin shows that the majority of known type I IFNs, as well as IFN g, are overexpressed in DM skin. In addition, both IFN-beta and IFN-gamma (but not other type I IFN) transcript levels were highly correlated with the degree of the in vivo IFN transcriptional response in DM skin.As in the blood and muscle, DM skin is characterized by an overwhelming presence of an IFN signature, although it is difficult to conclusively define this response as type I or type II. Understanding the significance of the IFN signature in this wide array of inflammatory diseases will be furthered by identification of the nature of the cells that both produce and respond to IFN, as well as which IFN subtype is biologically active in each diseased tissue.
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Watch Napoleon Dynamite – Season 1, Episode 1: Thundercone
After learning that his new acne cream makes him resistant to pain, Napoleon picks a fight with a bully at school. When the coach sees Napoleon’s strength in action, he invites him to join a local underground fight club. Meanwhile, Kip begins dating Misty, a new girl he met online, but is he the bad …
Mon, 16 Jan 2012 05:51:00 CST
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